The Institute for the Brain and Cognitive Sciences

Dr. Aoife Heaslip, Assistant Professor, Department of Molecular and Cell Biology, University of Connecticut

Host: Carol Teschke

Intracellular cargo transport in Toxoplasma gondii

The human pathogen Toxoplasma gondii (T. gondii) causes life-threatening disease in immunocompromised individuals and when infection occurs in utero. Survival and disease pathogenesis are dependent on host cell invasion, intracellular replication and egress, which results in destruction of the infected cells. In order to complete this lytic cycle, Toxoplasma must traffic proteins to three distinct secretory organelles, the micronemes, rhoptries and dense granules. In this talk I will present our recent work characterizing how actin and an unconventional myosin motor, MyoF regulate protein trafficking and vesicle transport in Toxoplasma.

Bio: Aoife Heaslip received her bachelor’s degree from University College Dublin and PhD degree from the University of Vermont under the mentorship of Dr. Gary Ward. Aoife then moved to Indiana University and worked as a postdoctoral associate with Dr. Ke Hu. She then returned to Vermont to complete a second postdoc with Dr. David Warshaw, an expert in myosin biophysics. I joined the MCB department as an assistant professor in 2017.

Heaslip website

Department of Molecular and Cell Biology

University of Connecticut

Announces the

Oral Dissertation Defense for the Doctoral Degree

Lorraine Burdick

B.S. University of Connecticut

Investigating the Developmental Fate of Fibro-Adipogenic Progenitors in Mouse Models of Fibrodysplasia Ossificans Progressiva

Wednesday, April 24, 2024

10:00 AM

BPB 131

Webex Link: https://uconn-cmr.webex.com/meet/lna09001

Major Advisor: David Goldhamer

Associate Advisor: Charles Giardina

Associate Advisor: Leighton Core

Examiner: Lawrence Silbart

Examiner: Caroline Dealy

Link to Current Draft of Dissertation

https://docs.google.com/document/d/11Cb4h7YolwT3UbVc4Um7_yzmNh9aMCT0zxS7b0y74Qc/edit?usp=sharing

Abstract: This talk will explore how learning more than one language influences children’s neural architecture as they learn to read. By studying Spanish-English and Chinese-English bilingual children using fNIRS, my research aims to understand how bilingual experiences shape the neural architecture for reading. Our findings offer insights into theoretical perspectives on bilingualism, literacy development, and neurodevelopmental plasticity.

Registration: https://tinyurl.com/UCONN-WTBY-RESEARCH

Some Reflections on Rosenbaum and Rubin’s Propensity Score Paper

Presented by Roderick J. Little
Richard D. Remington Distinguished University Professor of Biostatistics
Department of Biostatistics, University of Michigan

Wednesday, April 24, 2024
4:00 PM-5:00 PM ET
AUST 163
Webex Meeting Link
Coffee will be served at 3:30 pm in the Noether Lounge (AUST 326)

Rosenbaum and Rubin’s paper is highly cited because the basic idea is simple and insightful, and it has applications to important practical problems in treatment comparisons with observational data, and selection bias and nonresponse in surveys. I discuss several issues related to the method, including use of the propensity score for weighting or prediction, and two robust methods that use the propensity score as a covariate and can be more efficient that weighting when the weights are highly variable, namely Penalized Spline of Propensity Prediction (PSPP) and Penalized Spline of Propensity for Treatment Comparisons (PENCOMP). Approaches to addressing highly variable weights are discussed, including omitting variables in the propensity model that are unrelated to outcomes, and redefining the estimand.

Keywords: confounding by indication, nonresponse modeling, penalized spline of propensity, robust causal inference.

Speaker Bio:

Roderick J. Little is Richard D. Remington Distinguished University Professor of Biostatistics at the University of Michigan, where he also holds appointments in the Department of Statistics and the Institute for Social Research. He chaired the Biostatistics Department at Michigan for 11 years. He has over 250 publications, notably on methods for the analysis of data with missing values and model-based survey inference, and the application of statistics to diverse scientific areas, including medicine, demography, economics, psychiatry, aging and the environment. Little is an elected member of the International Statistical Institute, a Fellow of the American Statistical Association and the American Academy of Arts and Sciences, and a member of the National Academy of Medicine. In 2005, Little was awarded the American Statistical Association’s Wilks Medal for research contributions, and he gave the President’s Invited Address at the Joint Statistical Meetings. He was the COPSS Fisher Lecturer at the 2012 Joint Statistics Meetings.

Robert Makuch is a Professor in the Department of Biostatistics at the Yale School of Public Health and Director of the Regulatory Affairs Track. A graduate of the University of Connecticut (BA), University of Washington (MA – mathematics), and Yale University (MPhil, PhD), Professor Makuch worked at the National Cancer Institute (NCI) and the World Health Organization’s International Agency for Research on Cancer early in his career. He also worked for six months at the National Cancer Research Center in Tokyo, Japan.

He also was heavily involved in HIV research from the mid 80’s through the early-mid 90’s. He participated on the data monitoring committee for the original AZT vs. placebo randomized clinical trial in AIDS patients, and served on numerous committees for the NCI and the National Institute of Allergy and Infectious Diseases. He also worked closely with the Food and Drug Administration (FDA), developing and implementing more than 200 HIV studies. He also served as a Special Government Employee (SGE) to the FDA. He returned to Yale in 1986, and has worked extensively on methodologic issues in clinical trials and large population-based studies since. Another area of current interest involves detection of rare adverse drug events, especially in the post-marketing environment.

These areas of methodologic research evolved as a result of his continued interest (since the mid 1980s) in regulatory affairs science. In addition, Makuch developed a regulatory affairs track at YSPH for graduate and post-doctoral level students, and over the past 10 years has been the leader of more than 25 training programs for senior delegations of the Chinese Food and Drug Administration. His areas of medical application include cancer, HIV, arthritis, and cardiovascular disease.

In 2003, Makuch received the American Statistical Association Fellow Award for his numerous contributions to the field. In 2008, Makuch was received a Distinguished Alumni Award from the University of Connecticut. In 2012, Makuch was nominated to serve on the University of Connecticut Dean’s Advisory Board for the College of Liberal Arts and Sciences. He also has been a decades-long member of Phi Beta Kappa. He also developed a 5-year biostatistics training program in Japan, in collaboration with the Japanese government. His primary research interests continue to be methodologic issues in the design, conduct, analysis, and interpretation of clinical and large-population/epidemiologic studies. Design and sample size considerations for Phase IV studies is another active research area, in which a new class of hybrid designs has been proposed for scientific and regulatory purposes to detect rare adverse events.

On Wednesday, 4/24/24, Dr. Mark Rossi will be here at UConn for our seminar series from Rutgers Robert Wood Johnson Medical School. His talk will be titled “Lateral hypothalamic circuit control of feeding: Implications for obesity.”